Azoles are the main antifungal agents employed in clinical practice to treat invasive candidiasis.Nonetheless, their efficacy is limited by fungal resistance mechanisms, mainly the overexpression of efflux pumps.Consequently, candidiasis has a worrisome death rate of 75%.One potential strategy to overcome efflux-mediated resistance is to inhibit th
Summary: NMDA receptor (NMDAR) subunit composition plays a pivotal role in synaptic plasticity at excitatory synapses.Still, the mechanisms responsible for the synaptic retention of NMDARs following induction of plasticity need to be fully elucidated.Rabphilin3A (Rph3A) is involved in the stabilization of NMDARs at synapses through the formation of
Lobomycosis is a chronic cent dyyni disease caused by Lacazia loboi, which is endemic to the Amazon rainforest, where it affects forest dwellers in Brazil.There is no disease control program and no official therapeutic protocol.This situation contributes to an unknown disease prevalence and unmet needs of people disabled by this disease who seek ac
Introduction: Various treatment methods for drug abusers will result in different success rates.This is partly due to different neural assumptions and partly due to various rate of relapse in abusers because of different circumstances.Investigating the brain activation networks of treated subjects can reveal the hidden mechanisms of the therapeutic
Bacterial cellulose (BC) stands out as a prominent biopolymer of global importance, distinguished by its unique advantages over virginia mill works tobacco road acacia plant-derived cellulose.Strains such as Acetobacter xylinum, renowned for their proficient BC production, draw considerable attention in both commercial and biomedical areas.This res